Used this script at a customer environment to remove AD ExtensionAttributes, also you can use Add, Replace or Clear
get-aduser -properties extensionattribute1 -searchbase “OU=USERS,DC=local,DC=lan” -filter * | Where {$_.extensionattribute1 -eq “ANYTEXT” } | % { Set-Aduser -identity $_ -Remove @{extensionattribute1=@(“ANYTEXT”)}}